SAMHD1 抗体
Quick Overview for SAMHD1 抗体 (ABIN6944815)
抗原
See all SAMHD1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- Synthetic peptide within human SAMHD1 aa 600 to the C-terminus
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亚型
- IgG
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anti-SAM Domain and HD Domain 1 (SAMHD1) antibody
SAMHD1 适用: 人, 小鼠, 大鼠, 猴, 犬 WB, IF, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 1A1 unconjugated
anti-SAM Domain and HD Domain 1 (SAMHD1) antibodySAMHD1 适用: 人, 猴 WB, IF, FACS 宿主: 小鼠 Monoclonal 1F6 unconjugated
anti-SAM Domain and HD Domain 1 (SAMHD1) (AA 387-626) antibodySAMHD1 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-SAM Domain and HD Domain 1 (SAMHD1) (AA 1-626) antibodySAMHD1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-SAM Domain and HD Domain 1 (SAMHD1) (AA 1-314) antibodySAMHD1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SAM Domain and HD Domain 1 (SAMHD1) (Internal Region) antibodySAMHD1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-SAM Domain and HD Domain 1 (SAMHD1) (AA 1-626) antibodySAMHD1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-SAM Domain and HD Domain 1 (SAMHD1) (AA 256-370) antibodySAMHD1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SAM Domain and HD Domain 1 (SAMHD1) (AA 426-657) antibodySAMHD1 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SAM Domain and HD Domain 1 (SAMHD1) (AA 288-337) antibodySAMHD1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 12 months
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- SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))
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别名
- SAMHD1
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背景
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Synonyms: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, Dendritic cell-derived IFNG-induced protein, Monocyte protein 5, SAM domain and HD domain-containing protein 1, dNTPase, DCIP, MOP-5, SAMHD1, MOP5.
Background: SAMHD1 may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, macrophages and monocytes. It is an enzyme that exhibits phosphohydrolase activity, converting deoxynucleoside triphosphates (dNTPs) to inorganic phosphate (iPPP) and a 2'-deoxynucleoside (i.e. deoxynucleosides without a phosphate group). In doing so, SAMHD1 depletes the pool of dNTPs available to a reverse transcriptase for viral cDNA synthesis and thus prevents viral replication. SAMHD1 has also shown nuclease activity. Although a ribonuclease activity was described to be required for HIV-1 restriction, recent data confirmed that SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity.
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基因ID
- 25939
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UniProt
- Q9Y3Z3
抗原
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