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RAB5 抗体

This anti-RAB5 antibody is a 兔 单克隆 antibody detecting RAB5 in WB, IHC, IHC (p) 和 IF (cc). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6944732
发货至: 中国

Quick Overview for RAB5 抗体 (ABIN6944732)

抗原

See all RAB5 (RAB5A) 抗体
RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

适用

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人, 小鼠, 大鼠

宿主

  • 99
  • 11
  • 3
  • 2

克隆类型

  • 92
  • 23
单克隆

标记

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This RAB5 antibody is un-conjugated

应用范围

  • 85
  • 41
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  • 5
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Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

克隆位点

1A1
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    Human Rab5 between 150-250 amino acids

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IF(ICC) 1:50-200
    IHC()

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

    别名

    Rab5

    背景

    Synonyms: Ras-related protein Rab-5A, RAB5A, RAB5

    Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).

    基因ID

    5868

    UniProt

    P20339

    途径

    Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity
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