PP2A alpha/beta 抗体
Quick Overview for PP2A alpha/beta 抗体 (ABIN6944644)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠, 斑马鱼
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纯化方法
- Purified by Protein A.
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免疫原
- Human PP2A alpha + beta aa 250-350
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亚型
- IgG
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anti-PP2A alpha/beta (PP2A A/B) (AA 205-309) antibody
PP2A A/B 适用: 人, 小鼠 WB, IF (cc), IF (p), ELISA, FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-PP2A alpha/beta (PP2A A/B) (pTyr307) antibodyPP2A A/B 适用: 人, 大鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-PP2A alpha/beta (PP2A A/B) antibodyPP2A A/B 适用: 人, 小鼠 WB, IP 宿主: 小鼠 Monoclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- PP2A alpha/beta (PP2A A/B)
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别名
- PP2A alpha + beta
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背景
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Synonyms: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Replication protein C, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, PP2A-alpha, RP-C, PPP2CA, PP2A-beta, PPP2CB
Background: The catalytic subunit of protein phosphatase 2A (PP2A) is inactivated by in vitro phosphorylation of Tyr-307 by receptor and nonreceptor protein tyrosine kinases. The catalytic subunit of PP2A is phosphorylated by tyrosine-specific protein kinases and associates with a variety of regulatory subunits. Phosphorylation is enhanced in the presence of the phosphatase inhibitor okadaic acid, consistent with an autodephosphorylation reaction. Phosphorylation is catalyzed by p60v-src, p56lck, epidermal growth factor receptors, and insulin receptors. Transient deactivation of PP2A might enhance transmission of cellular signals through kinase cascades within cells. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases.
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UniProt
- P62714, P67775
抗原
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