Recombinant NCK1 抗体 (AA 1-200)
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北京 101111
Quick Overview for Recombinant NCK1 抗体 (AA 1-200) (ABIN6944225)
抗原
See all NCK1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-200
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原理
- NCK1 Recombinant Antibody
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预测反应
- Human,Mouse,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant protein corresponding human Nck1 aa 1-200
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亚型
- IgG
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应用备注
- WB(1:300-5000), FCM(1:200-400), IHC-P(1:50-200), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 12 months
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- NCK1 (NCK Adaptor Protein 1 (NCK1))
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别名
- NCK1
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背景
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Synonyms: Cytoplasmic protein NCK1, NCK adaptor protein 1, SH2/SH3 adaptor protein NCK-alpha, Nck-1, NCK1, NCK.
Background: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
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基因ID
- 4690
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UniProt
- P16333
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途径
- TCR Signaling, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
抗原
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