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MYST1 抗体

This anti-MYST1 antibody is a 兔 单克隆 antibody detecting MYST1 in WB, IF (cc), IF (p), IHC (p) 和 FACS. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6943861
发货至: 中国

Quick Overview for MYST1 抗体 (ABIN6943861)

抗原

See all MYST1 (KAT8) 抗体
MYST1 (KAT8) (K(lysine) Acetyltransferase 8 (KAT8))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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单克隆

标记

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This MYST1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

克隆位点

2B1
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    Recombinant protein within N-terminal human KAT8.

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    MYST1 (KAT8) (K(lysine) Acetyltransferase 8 (KAT8))

    别名

    KAT8

    背景

    Synonyms: Histone acetyltransferase KAT8, Lysine acetyltransferase 8, MOZ YBF2/SAS3 SAS2 and TIP60 protein 1, MYST-1, hMOF, KAT8, MOF, MYST1

    Background: Dosage compensation ensures that males with a single X chromosome and females with two X chromosomes have the same amount of most X-linked gene products. In Drosophila, this is acheived by enhancing the level of transcription of the X chromosome in males. Proteins such as maleless, male specific lethal 1, 2 and 3, and males absent on the first (MOF) form a dosage compensation complex (DCC) that is required for the twofold increase of transcription of the male X chromosome. The DCC is preferentially associated with many sites on the X chromosome in somatic cells of males. The binding of the DCC to the X chromosome is dependent upon histone 4 acetylation at lysine 16, which is accomplished by MOF. In mammals, MOF (also designated hMOF, MYST1, or MOZ) belongs to the MYST family of histone acetyl transferases which are characterized by a unique C2HC-type zinc finger close to their HAT domains. MOF utilizes the zinc finger domain to contact the globular part of the nucleosome as well as the histone H4 N-terminal tail substrate. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone acetyltransferases.

    基因ID

    84148

    UniProt

    Q9H7Z6
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