HNRNPC 抗体
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北京 101111
Quick Overview for HNRNPC 抗体 (ABIN6943686)
抗原
See all HNRNPC 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- hnRNP C1+C2 (9F7) Monoclonal Antibody
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交叉反应
- 人, 小鼠, 大鼠, 斑马鱼
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纯化方法
- Purified by Protein A.
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免疫原
- Full length protein
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亚型
- IgG
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应用备注
- WB(1:300-5000), FCM(1:20-100), IHC-P(1:200-400), IF(ICC)(1:50-200), IHC()
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))
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别名
- hnRNP C1+C2
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背景
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Synonyms: Heterogeneous nuclear ribonucleoproteins C1/C2, hnRNP C1/C2, HNRNPC
Background: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).
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基因ID
- 3183
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UniProt
- P07910
抗原
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