IQSEC1 抗体 (AA 451-550) (HRP)
Quick Overview for IQSEC1 抗体 (AA 451-550) (HRP) (ABIN6943527)
抗原
See all IQSEC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 451-550
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Dog,Sheep,Pig,Horse,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human GEP100
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亚型
- IgG
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anti-IQ Motif and Sec7 Domain 1 (IQSEC1) (N-Term) antibody
IQSEC1 适用: 小鼠, 人, 大鼠 WB, ELISA, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif and Sec7 Domain 1 (IQSEC1) (AA 180-380) antibodyIQSEC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))
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别名
- GEP100/IQSEC1
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背景
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Synonyms: ADP-ribosylation factors guanine nucleotide-exchange protein 100, ADP-ribosylation factors guanine nucleotide-exchange protein 2, ARF GEP100, ARFGEP100, BRAG2, Brefeldin A resistant ARF GEF2, Brefeldin-resistant Arf-GEF 2 protein, GEP100, IQ motif and Sec7 domain 1, IQ motif and SEC7 domain-containing protein 1, IQEC1_HUMAN, Iqsec1, Kiaa0763.
Background: The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF6 plays a role in protein trafficking near the plasma membrane, including receptor recycling, cell adhesion and cell migration. ARF6 colocalizes with the ARF guanine nucleotide-exchange protein (GEP) BRAG2, also designated GEP100. BRAG2 is ubiquitously expressed as two isoforms, BRAG2a and BRAG2b, which can cycle between the cytoplasm and the nucleus. BRAG2, via its interaction with ARF6, is involved in the regulation of cell adhesion by controlling Integrin 1 endocytosis and E-cadherin redistribution. BRAG2 has also been shown to bind directly to Tyr1068/1086-phosphorylated EGFR to activate ARF6, which induces tumor invasion in MCF7 cells. Therefore, BRAG2 may contribute to the metastasis and malignancy of some breast cancer cells.
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基因ID
- 9922
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UniProt
- Q6DN90
抗原
-
