GBA 抗体
Quick Overview for GBA 抗体 (ABIN6943522)
抗原
See all GBA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Human GBA between 50 to 150 amino acids
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亚型
- IgG
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anti-Glucosidase, Beta, Acid (GBA) (AA 146-235) antibody
GBA 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 2E2 unconjugated
anti-Glucosidase, Beta, Acid (GBA) (AA 117-214) antibodyGBA 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glucosidase, Beta, Acid (GBA) antibodyGBA 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glucosidase, Beta, Acid (GBA) (AA 334-498) antibodyGBA 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glucosidase, Beta, Acid (GBA) antibodyGBA 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glucosidase, Beta, Acid (GBA) (C-Term) antibodyGBA 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Glucosidase, Beta, Acid (GBA) (AA 255-509) antibodyGBA 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glucosidase, Beta, Acid (GBA) (AA 215-343) antibodyGBA 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glucosidase, Beta, Acid (GBA) (AA 146-235) antibodyGBA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H4 unconjugated
anti-Glucosidase, Beta, Acid (GBA) (AA 1-536) antibodyGBA 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- GBA (Glucosidase, Beta, Acid (GBA))
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别名
- GBA
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背景
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Synonyms: Glucosylceramidase, Acid beta-glucosidase, Alglucerase, Beta-glucocerebrosidase, D-glucosyl-N-acylsphingosine glucohydrolase, Imiglucerase, Beta-GC, GBA
Background: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PubMed:9201993, PubMed:24211208). Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation (PubMed:19279011). Also plays a role in cholesterol metabolism (PubMed:24211208, PubMed:26724485). May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol (PubMed:24211208, PubMed:26724485). The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction (PubMed:24211208). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (PubMed:26724485). Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol (PubMed:24211208, PubMed:26724485).
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基因ID
- 2629
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UniProt
- P04062
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途径
- Cellular Glucan Metabolic Process
抗原
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