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FTO 抗体

Name: FTO 抗体
SKU: ABIN6943480
Availability: OutOfStock

This anti-FTO antibody is a 兔单克隆 antibody detecting FTO in WB, IHC (p), IF (cc), IF (p) 和 FACS. Suitable for 人.

产品编号 ABIN6943480

发货至: 中国

Quick Overview for FTO 抗体 (ABIN6943480)

抗原

See all FTO 抗体

FTO (Fat Mass and Obesity-Associated (FTO))

适用

人

宿主

兔

克隆类型

单克隆

标记

This FTO antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)

克隆位点

12A1

Discover our top product FTO Primary Antibody

交叉反应

人

纯化方法

Purified by Protein A.

免疫原

Recombinant protein within human FTO aa 350-500

亚型

IgG
anti-Fat Mass and Obesity-Associated (FTO) antibody
FTO 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Monoclonal 4G9 unconjugated Recombinant Antibody

anti-Fat Mass and Obesity-Associated (FTO) antibody
FTO 适用: 小鼠 WB, ELISA, IHC, IP 宿主: 小鼠 Monoclonal FT62-6 unconjugated

anti-Fat Mass and Obesity-Associated (FTO) antibody
FTO 适用: 人 WB, ELISA, IHC, IP 宿主: 小鼠 Monoclonal AG103 unconjugated

anti-Fat Mass and Obesity-Associated (FTO) antibody
FTO 适用: 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Fat Mass and Obesity-Associated (FTO) antibody
FTO 适用: 人, 小鼠, 大鼠, 犬, Cow, 绵羊, 马, 灵长类 WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 5-2H10 unconjugated

anti-Fat Mass and Obesity-Associated (FTO) antibody
FTO 适用: 人, 小鼠, 大鼠 WB, ELISA, IP 宿主: 小鼠 Monoclonal FT86-4 unconjugated

anti-Fat Mass and Obesity-Associated (FTO) (AA 416-505) antibody
FTO 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Fat Mass and Obesity-Associated (FTO) (N-Term) antibody
FTO 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 5-2H10 unconjugated

anti-Fat Mass and Obesity-Associated (FTO) (AA 1-30), (N-Term) antibody
FTO 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB21572 unconjugated

anti-Fat Mass and Obesity-Associated (FTO) antibody
FTO 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

有效期

12 months
抗原

FTO (Fat Mass and Obesity-Associated (FTO))

别名

FTO

背景

Synonyms: Alpha-ketoglutarate-dependent dioxygenase FTO, Fat mass and obesity-associated protein, FTO, KIAA1752, GDFD, ALKBH9, BMIQ14, Fatso.
Background: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N6-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Also acts as a tRNA demethylase by removing N1-methyladenine from various tRNAs. Also able to repair alkylated DNA and RNA by oxidative demethylation. Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation. Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells. Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs. Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression

基因ID

79068

UniProt

Q9C0B1