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Recombinant CXCR3 抗体 (AA 250-350)

This 兔 单克隆 antibody specifically detects CXCR3 in WB, IHC (p) 和 IF (cc). It exhibits reactivity toward 人.
产品编号 ABIN6942741
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Recombinant CXCR3 抗体 (AA 250-350) (ABIN6942741)

抗原

See all CXCR3 抗体
CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

抗体类型

Recombinant Antibody

适用

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宿主

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克隆类型

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单克隆

标记

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This CXCR3 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))
  • 抗原表位

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    AA 250-350

    原理

    CXCR3 Recombinant Antibody

    交叉反应

    纯化方法

    Purified by Protein A.

    免疫原

    Human CXCR3 aa 250-350

    亚型

    IgG
  • 应用备注

    WB(1:500-2000), IHC-P(1:200-400), IF(ICC)(1:50-200)

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • 抗原

    CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

    别名

    CXCR3

    背景

    Synonyms: C-X-C chemokine receptor type 3, CKR-L2, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, CXC-R3, CXCR-3, IP-10 receptor, IP-10 receptor, CD183, CXCR3, GPR9

    Background: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis response. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.

    基因ID

    2833

    UniProt

    P49682
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