Recombinant CXCR3 抗体 (AA 250-350)
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Quick Overview for Recombinant CXCR3 抗体 (AA 250-350) (ABIN6942741)
抗原
See all CXCR3 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 250-350
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原理
- CXCR3 Recombinant Antibody
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- Human CXCR3 aa 250-350
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亚型
- IgG
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应用备注
- WB(1:500-2000), IHC-P(1:200-400), IF(ICC)(1:50-200)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
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别名
- CXCR3
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背景
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Synonyms: C-X-C chemokine receptor type 3, CKR-L2, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, CXC-R3, CXCR-3, IP-10 receptor, IP-10 receptor, CD183, CXCR3, GPR9
Background: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis response. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.
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基因ID
- 2833
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UniProt
- P49682
抗原
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