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DPP4 抗体

DPP4 适用: 人, 大鼠, 小鼠 FACS, WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 4A9 unconjugated
产品编号 ABIN6942419
发货至: 中国
  • 抗原 See all DPP4 抗体
    DPP4 (Dipeptidyl-Peptidase 4 (DPP4))
    适用
    • 119
    • 40
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    • 5
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    人, 大鼠, 小鼠
    宿主
    • 82
    • 56
    • 13
    • 3
    • 1
    克隆类型
    • 78
    • 75
    • 1
    单克隆
    标记
    • 79
    • 24
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    This DPP4 antibody is un-conjugated
    应用范围
    • 67
    • 65
    • 43
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    Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    Human CD26 aa 600 to the C-terminus
    克隆位点
    4A9
    亚型
    IgG
    Top Product
    Discover our top product DPP4 Primary Antibody
  • 应用备注
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    DPP4 (Dipeptidyl-Peptidase 4 (DPP4))
    别名
    CD26 (DPP4 产品)
    背景

    Synonyms: Dipeptidyl peptidase 4, ADABP, Adenosine deaminase complexing protein 2, Dipeptidyl peptidase IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form, ADCP-2, DPP IV, DPP4

    Background: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

    基因ID
    1803
    UniProt
    P27487
    途径
    Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity
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