ARNTL 抗体
Quick Overview for ARNTL 抗体 (ABIN6942287)
抗原
See all ARNTL 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- C terminal human BMAL1
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亚型
- IgG
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anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) (AA 1-169) antibody
ARNTL 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) (Lys538) antibodyARNTL 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) (Internal Region) antibodyARNTL 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) antibodyARNTL 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 1C5 unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) antibodyARNTL 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) antibodyARNTL 适用: 人 WB, FACS, IF 宿主: 小鼠 Monoclonal 1D1 unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) antibodyARNTL 适用: 人, 大鼠, 犬 WB, FACS, IF 宿主: 小鼠 Monoclonal 3G9 unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) (AA 44-91) antibodyARNTL 适用: 人, Cow, 绵羊, 豚鼠, 马, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) (N-Term) antibodyARNTL 适用: 人, 大鼠, 小鼠, Cow, 犬, 绵羊, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) (AA 151-250) antibodyARNTL 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))
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别名
- BMAL1
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背景
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Synonyms: ARNTL, Aryl hydrocarbon receptor nuclear translocator-like protein 1, Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, Class E basic helix-loop-helix protein 5, Member of PAS protein 3, PAS domain-containing protein 3, bHLH-PAS protein JAP3, bHLHe5, BHLHE5, BMAL1, MOP3, PASD3.
Background: Transcriptional activator which forms a core component of the circadian clock. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway.
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基因ID
- 406
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UniProt
- O00327
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途径
- Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Warburg Effect
抗原
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