Melanoma Associated Antigen (KBA.62) 抗体
The 小鼠 单克隆 anti-Melanoma Associated Antigen (KBA.62) antibody (Clone KBA-62) (ABIN6941354) specifically detects Melanoma Associated Antigen (KBA.62) in IF 和 IHC.
The antibody is reactive with 人 samples.
产品编号 ABIN6941354
发货至:
中国
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北京 101111
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Quick Overview for Melanoma Associated Antigen (KBA.62) 抗体 (ABIN6941354)
抗原
Melanoma Associated Antigen (KBA.62)
适用
人
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Immunofluorescence (IF), Immunohistochemistry (IHC)
克隆位点
KBA-62
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原理
- KBA.62 (Melanoma Associated Antigen) Antibody
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特异性
- KBA.62 is a novel anti-melanoma antibody. It reacts positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity. Moreover, it reacts positively against junctional nevus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes. KBA.62 antibody is useful in identifying malignant melanomas. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, sarcomas, spindle cell carcinomas and various types of mesenchymal neoplasms. A keratin-negative, vimentin-rich neoplasm that immuno-reacts with antibody to S100 protein and with KBA.62 antibody is, with rare exception, a melanoma. Anti-KBA.62 is a useful additional marker for melanoma, specifically in desmoplastic/spindle cell cases and in the context of micro-metastasis in sentinel lymph node.
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纯化方法
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Human KAL cells derived from lymph node metastasis of malignant melanoma
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亚型
- IgG1, kappa
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应用备注
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Positive Control: SK-MEL-13 and SK-MEL-19 melanoma cell lines. Human melanoma tissues.
Known Application: Immunofluorescence (0.5-1 μg/mL), Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Melanoma Associated Antigen (KBA.62)
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别名
- KBA.62 (Melanoma Associated Antigen)
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背景
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Human Melanoma Associated Antigen, KBA.62
SK-MEL-13 and SK-MEL-19 melanoma cell lines. Human melanoma tissues.
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分子量
- 135 and 128kDa and two weak bands of 88 and 73kDa)| (140
抗原
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