CYP3A1 抗体
This anti-CYP3A1 antibody is a 小鼠 单克隆 antibody detecting CYP3A1 in WB, ELISA, Coat 和 FACS. Suitable for 大鼠, 人, 小鼠 和 Pig.
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Quick Overview for CYP3A1 抗体 (ABIN6941330)
抗原
CYP3A1 (Cyp3a1)
(Cytochrome P450, Family 3, Subfamily A, Polypeptide 1 (Cyp3a1))
适用
大鼠, 人, 小鼠, Pig
宿主
小鼠
克隆类型
单克隆
标记
This CYP3A1 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Coating (Coat), Flow Cytometry (FACS)
克隆位点
P6
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特异性
- Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound, either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver, these substrates include toxins, drugs, and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies, the CYP1 family is involved in drug metabolism and includes 3 subfamilies, 3 genes and 1 pseudogene. The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. P6 is highly specific for members of the CYP 3A gene family and cross reacts with CY 3A4 in human, CYP 3A in rat and potentially CYP 3A11 (based on inducibility) in mice.
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纯化方法
- Purified by Protein A/G
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免疫原
- Full length protein (Rat). Rat liver cytochrome P450 3A1.
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亚型
- IgG1 kappa
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anti-Cytochrome P450, Family 3, Subfamily A, Polypeptide 1 (Cyp3a1) (AA 231-330) antibody
Cyp3a1 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Positive Control: HeLa cells. Liver or Cardiac muscle.
Known Application: ELISA (For coating, order antibody without BSA), Flow Cytometry (0.5-1 μg/million cells), ,Western Blot (0.5-1.0 μg/mL),Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- CYP3A1 (Cyp3a1) (Cytochrome P450, Family 3, Subfamily A, Polypeptide 1 (Cyp3a1))
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别名
- CYP3A1
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分子量
- 51kDa
抗原
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