MVP 抗体
Quick Overview for MVP 抗体 (ABIN6941285)
抗原
See all MVP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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                                            特异性
- Recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for 70 % of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
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                                            纯化方法
- Purified by Protein A/G
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                                            免疫原
- proteins precipitated from human breast cancer MCF-7 cells
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                                            亚型
- IgG1 kappa
 
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                                            应用备注
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                        Positive Control: MCF-7/HeLa, breast tumors. Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined. 
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                                            限制
- 仅限研究用
 
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                                            浓度
- 200 μg/mL
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                                            缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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                                            储存液
- Sodium azide
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                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- 4 °C,-80 °C
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                                            储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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                                            有效期
- 24 months
 
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    - MVP (Major Vault Protein (MVP))
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                                            别名
- MVP
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                                            分子量
- 104-110kDa
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                                            基因ID
- 9961
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                                            UniProt
- Q14764
 抗原
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