CD8 alpha 抗体 (C-Term, Cytoplasmic Domain)
Quick Overview for CD8 alpha 抗体 (C-Term, Cytoplasmic Domain) (ABIN6941082)
抗原
See all CD8 alpha (CD8A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term, Cytoplasmic Domain
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免疫原
- Recombinant fragment from C-terminal cytoplasmic domain of alpha chain of human CD8 (exact sequence is proprietary).
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亚型
- IgG
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应用备注
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Positive Control: HuT78 or hPBL. Tonsil.
Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- 200 µg/mL of antibody Purified from rabbit anti-serum by Protein A chromatography. Supplied in 10 mM PBS, pH 7.4 with 0.05 % BSA and 0.05 % sodium azide. Contact us if you require this antibody in a different format.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- CD8 alpha (CD8A) (CD8a Molecule (CD8A))
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别名
- CD8A
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背景
- CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
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分子量
- 32kDa
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基因ID
- 925
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UniProt
- P01732
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途径
- TCR Signaling
抗原
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