ZFYVE28 抗体
Quick Overview for ZFYVE28 抗体 (ABIN6940433)
抗原
See all ZFYVE28 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
纯化方法
- Purified by Protein A/G
-
免疫原
- Recombinant full-length human ZFYVE28 protein
-
亚型
- IgG2a kappa
-
-
anti-Zinc Finger, FYVE Domain Containing 28 (ZFYVE28) (AA 1-887) antibody
ZFYVE28 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 28 (ZFYVE28) (AA 131-180) antibodyZFYVE28 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 28 (ZFYVE28) (N-Term) antibodyZFYVE28 适用: 人, 小鼠, 大鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 28 (ZFYVE28) (AA 611-642), (C-Term) antibodyZFYVE28 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 28 (ZFYVE28) (AA 604-633), (C-Term) antibodyZFYVE28 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Positive Control: PC3 cells. Testis, Brain, Colon, Kidney or Stomach.
Known Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
-
限制
- 仅限研究用
-
-
-
浓度
- 200 μg/mL
-
缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-80 °C
-
储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
-
有效期
- 24 months
-
-
- ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))
-
别名
- ZFYVE28
-
背景
- ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs.
-
分子量
- 96kDa
-
基因ID
- 57732
-
途径
- EGFR Signaling Pathway
抗原
-
