MTAP 抗体 (AA 97-196)
Quick Overview for MTAP 抗体 (AA 97-196) (ABIN6940087)
抗原
See all MTAP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 97-196
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特异性
- Recognizes a protein of 31 kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
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纯化方法
- Purified by Protein A/G
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免疫原
- Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary)
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亚型
- IgG2b kappa
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anti-Methylthioadenosine phosphorylase (MTAP) (AA 1-154) antibody
MTAP 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G4 unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 1-283) antibodyMTAP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) antibodyMTAP 适用: 人 WB, IP, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 97-196) antibodyMTAP 适用: 人 WB, IHC, ELISA, Coat, StM 宿主: 兔 Monoclonal MTAP-3137R unconjugated Recombinant Antibody
anti-Methylthioadenosine phosphorylase (MTAP) (AA 97-196) antibodyMTAP 适用: 人 IHC, StM, ISt 宿主: 小鼠 Monoclonal rMTAP-1813 unconjugated Recombinant Antibody
anti-Methylthioadenosine phosphorylase (MTAP) (Internal Region) antibodyMTAP 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 1-283) antibodyMTAP 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 8-37), (N-Term) antibodyMTAP 适用: 人 WB 宿主: 兔 Polyclonal RB42759 unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 1-283) antibodyMTAP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C8 unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 6-275) antibodyMTAP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Positive Control: HepG2, A431, HeLa, HAP1 or MCF-7 cells. Kidney.
Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- MTAP (Methylthioadenosine phosphorylase (MTAP))
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别名
- MTAP
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分子量
- 31kDa
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基因ID
- 4507
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UniProt
- Q13126
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途径
- Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process
抗原
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