TOX3 抗体 (AA 251-389)
Quick Overview for TOX3 抗体 (AA 251-389) (ABIN6939531)
抗原
See all TOX3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 251-389
-
特异性
- It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
-
纯化方法
- Purified by Protein A/G
-
免疫原
- Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary)
-
亚型
- IgG1 kappa
-
-
anti-TOX High Mobility Group Box Family Member 3 (TOX3) (AA 214-242) antibody
TOX3 适用: 人, 小鼠 FACS, WB, IHC (p) 宿主: 兔 Polyclonal RB24743 unconjugated
anti-TOX High Mobility Group Box Family Member 3 (TOX3) (AA 8-305) antibodyTOX3 适用: 人 WB, IF, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TOX High Mobility Group Box Family Member 3 (TOX3) (AA 200-400) antibodyTOX3 适用: 人 FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal TOX3-1123 unconjugated
-
-
应用备注
-
Positive Control: SH-SY5Y, MDA-MB-435 cells. Brain or breast or gastric Carcinoma.
Known Application: ELISA (For coating, order Ab without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
-
限制
- 仅限研究用
-
-
-
浓度
- 200 μg/mL
-
缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-80 °C
-
储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
-
有效期
- 24 months
-
-
- TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))
-
别名
- TOX3
-
分子量
- 63kDa
-
基因ID
- 27324
-
UniProt
- O15405
-
途径
- Chromatin Binding
抗原
-
