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ALPL 抗体

This anti-ALPL antibody is a 小鼠 单克隆 antibody detecting ALPL in FACS, IF 和 IHC (fro). Suitable for 人 和 Cow.
产品编号 ABIN6939449
发货至: 中国

Quick Overview for ALPL 抗体 (ABIN6939449)

抗原

See all ALPL 抗体
ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

适用

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人, Cow

宿主

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小鼠

克隆类型

  • 92
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单克隆

标记

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This ALPL antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

克隆位点

V17-1
  • 纯化方法

    Purified by Protein A/G

    免疫原

    Bovine intestinal alkaline phosphatase

    亚型

    IgG1 kappa
  • 应用备注

    Positive Control: Intestine.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Immunohistochemistry (Frozen) (0.5-1 μg/mL for 30 minutes at RT)Optimal dilution for a specific application should be determined.

    限制

    仅限研究用
  • 浓度

    200 μg/mL

    缓冲液

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-80 °C

    储存方法

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    有效期

    24 months
  • 抗原

    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

    别名

    ALPL

    背景

    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

    分子量

    55kDa

    基因ID

    249

    UniProt

    P05186
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