Thymidine Phosphorylase 抗体
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- 抗原 See all Thymidine Phosphorylase (TYMP) 抗体
- Thymidine Phosphorylase (TYMP)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Thymidine Phosphorylase antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
- 交叉反应 （详细）
- Human. Mouse. Rat.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein
- 克隆位点
- P-GF-44C
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product TYMP Primary Antibody
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anti-Thymidine Phosphorylase (TYMP) (AA 311-482) antibody
TYMP 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1H7 unconjugated
anti-Thymidine Phosphorylase (TYMP) (AA 29-305) antibodyTYMP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) (AA 1-200) antibodyTYMP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) antibodyTYMP 适用: 人, 大鼠, 小鼠 IHC, StM 宿主: 兔 Monoclonal TYMP-2890R unconjugated Recombinant Antibody
anti-Thymidine Phosphorylase (TYMP) (N-Term) antibodyTYMP 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) (AA 1-482) antibodyTYMP 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) antibodyTYMP 适用: 人, 大鼠, 小鼠 WB, IHC, IP, StM 宿主: 小鼠 Monoclonal P-GF-44C unconjugated
anti-Thymidine Phosphorylase (TYMP) antibodyTYMP 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) (AA 13-254) antibodyTYMP 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) (N-Term) antibodyTYMP 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Known_Application: Western Blot (1-2 μg/mL), Immunoprecipitation (0.5-1 μg/500 μg protein lysate), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HUVEC cells. Breast,Spleen, Bladder, Lung or Kaposi tumors.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- Thymidine Phosphorylase (TYMP)
- 别名
- TYMP (TYMP 产品)
- 别名
- ECGF antibody, ECGF1 antibody, MEDPS1 antibody, MNGIE antibody, MTDPS1 antibody, PDECGF antibody, TP antibody, hPD-ECGF antibody, 2900072D10Rik antibody, Ecgf1 antibody, PD-ECGF antibody, Pdgfec antibody, typh antibody, thymidine phosphorylase antibody, thymidine phosphorylase DeoA antibody, AMP phosphorylase antibody, Thymidine phosphorylase antibody, TYMP antibody, Tymp antibody, deoA antibody, Dd586_0614 antibody, Kvar_4413 antibody, NMAG_RS19330 antibody, Snov_1187 antibody, Fbal_2856 antibody, Ftrac_2071 antibody, Intca_1216 antibody, ARCVE_RS10415 antibody, Sphch_4174 antibody, Sinme_3461 antibody, METOK_RS06355 antibody, Mesop_1831 antibody, typh antibody
- 背景
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ECGF, ECGF1, Gliostatin, hPD-ECGF, MEDPS1, MNGIE, MTDPS1, PD-ECGF, PDECGF, Platelet-derived endothelial cell growth factor, TdRPase, Thymidine phosphorylase, TP, Tymp,Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker)
Cellular localisation: Cytoplasmic and Nuclear - 分子量
- 55kDa
- 基因ID
- 1890, 180903
- UniProt
- P19971
- 途径
- Signaling Events mediated by VEGFR1 and VEGFR2
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