ANO1 抗体 (AA 904-986)
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北京 101111
Quick Overview for ANO1 抗体 (AA 904-986) (ABIN6938597)
抗原
See all ANO1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 904-986
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原理
- DOG-1 / TMEM16A (Marker for Gastrointestinal Stromal Tumors) Antibody
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特异性
- Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4 % vs. 94.7 %.
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交叉反应 （详细）
- Human. Others not known.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- A synthetic peptide from human DOG-1 protein (aa 904-986), conjugated to a carrier protein. (
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亚型
- IgG1, kappa
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anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 151-250) antibody
ANO1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 20-239) antibodyANO1 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 2-101) antibodyANO1 适用: 人 IHC 宿主: 小鼠 Monoclonal DG1-1484 unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 1-151) antibodyANO1 适用: 人 IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 2-101) antibodyANO1 适用: 人 IHC 宿主: 小鼠 Monoclonal 201M unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (Middle Region) antibodyANO1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (Internal Region) antibodyANO1 适用: 人, 小鼠, 大鼠 IHC, IF, WB, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) antibodyANO1 适用: 人 IHC 宿主: 小鼠 Monoclonal rDG1-447 unconjugated Recombinant Antibody
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 2-101) antibodyANO1 适用: 人, 犬 IHC 宿主: 兔 Monoclonal DG1-2564R unconjugated Recombinant Antibody
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 628-731) antibodyANO1 适用: 人 IF, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistology (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
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别名
- TMEM16A
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背景
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Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1, TAOS2, ORAOV2, TMEM16A
Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
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分子量
- ~114kDa
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基因ID
- 55107, 503074
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UniProt
- Q5XXA6
抗原
-
