ANO1 抗体 (AA 2-101)
Quick Overview for ANO1 抗体 (AA 2-101) (ABIN6938591)
抗原
See all ANO1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 2-101
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特异性
- Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human DOG-1 protein fragment (aa 2-101) (exact sequence is proprietary)
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亚型
- IgG2b kappa
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anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 151-250) antibody
ANO1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 20-239) antibodyANO1 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 1-151) antibodyANO1 适用: 人 IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 2-101) antibodyANO1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal DG1-1484 unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 2-101) antibodyANO1 适用: 人 IHC 宿主: 小鼠 Monoclonal MSVA-201M unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (Middle Region) antibodyANO1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 2-101) antibodyANO1 适用: 人 IHC, StM 宿主: 兔 Monoclonal DG1-2564R unconjugated Recombinant Antibody
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) antibodyANO1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal rDG1-447 unconjugated Recombinant Antibody
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (Internal Region) antibodyANO1 适用: 人, 小鼠, 大鼠 IHC, IF, WB, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 1, Calcium Activated Chloride Channel (ANO1) (AA 628-731) antibodyANO1 适用: 人 IF, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
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别名
- TMEM16A
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背景
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Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1, TAOS2, ORAOV2, TMEM16A,DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker)
Cellular localisation: Cell Surface and Cytoplasm -
分子量
- ~114kDa
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基因ID
- 55107, 503074
抗原
-
