Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) 抗体
Quick Overview for Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) 抗体 (ABIN6938445)
抗原
See all Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 356-475
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特异性
- Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II) four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin and spectrin are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin I (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin III is highly homologous to both spectrin I and spectrin II. Spectrin III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment (around aa356-475) of human SPTBN2 protein (exact sequence is proprietary)
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亚型
- IgG2b kappa
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anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) antibody
SPTBN2 适用: 人, 小鼠, 大鼠 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) antibodySPTBN2 适用: 人 WB, FACS, IHC, ELISA, Coat, StM 宿主: 兔 Monoclonal SPTBN2-2894R unconjugated Recombinant Antibody
anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) antibodySPTBN2 适用: 人 WB, IF, IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal SPTBN2-1778 unconjugated
anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) antibodySPTBN2 适用: 人, 小鼠, 大鼠 WB, FACS, IF, IHC, StM 宿主: 小鼠 Monoclonal SPTBN2-1584 unconjugated
anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) antibodySPTBN2 适用: 人 WB, FACS, IF, IHC, StM 宿主: 小鼠 Monoclonal SPTBN2-1583 unconjugated
anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) antibodySPTBN2 适用: 人 WB, FACS, IF, IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal SPTBN2-1582 unconjugated
anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) antibodySPTBN2 适用: 人, 小鼠, 大鼠 WB, IHC, StM 宿主: 兔 Monoclonal SPTBN2-2979R unconjugated Recombinant Antibody
anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) antibodySPTBN2 适用: 人 WB, FACS, IF, IHC, StM 宿主: 兔 Monoclonal SPTBN2-2887R unconjugated Recombinant Antibody
anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) antibodySPTBN2 适用: 人 WB, IHC, ELISA, Coat 宿主: 小鼠 Monoclonal rSPTBN2-1778 unconjugated Recombinant Antibody
anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 643-720) antibodySPTBN2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D9 unconjugated
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应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells), (,Immunofluorescence (1-2 μg/mL), ,Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: PANC-1, HeLa cells. Pancreas or Liver.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- Spectrin, Beta, Non-erythrocytic 2 (SPTBN2)
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别名
- SPTBN2
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背景
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Beta III spectrin, SCA5, Spectrin beta chain brain 2, Spectrin beta non-erythrocytic 2, Spectrin non-erythroid beta chain 2, Spinocerebellar ataxia 5, SPTBN2,Spectrin beta III (SPTBN2)
Cellular localisation: Cell Surface -
分子量
- 246kDa
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基因ID
- 6712, 26915
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UniProt
- O15020
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途径
- Regulation of Actin Filament Polymerization, Synaptic Vesicle Exocytosis
抗原
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