Spastin 抗体
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- 抗原 See all Spastin (SPAST) 抗体
- Spastin (SPAST)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Spastin antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40 % of all autosomal dominant HSPs.
- 交叉反应 （详细）
- Human. Mouse. Rat.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant full-length human Spastin protein.
- 克隆位点
- Sp 3G11-1
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product SPAST Primary Antibody
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anti-Spastin (SPAST) (AA 200-304) antibody
SPAST 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F5 unconjugated
anti-Spastin (SPAST) (AA 551-616) antibodySPAST 适用: 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Spastin (SPAST) antibodySPAST 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Spastin (SPAST) (AA 200-304) antibodySPAST 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A12 unconjugated
anti-Spastin (SPAST) antibodySPAST 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Spastin (SPAST) antibodySPAST 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, Coat, StM 宿主: 小鼠 Monoclonal Sp 3G11-1 unconjugated
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- 应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. Rat brain extract.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- Spastin (SPAST)
- 别名
- SPAST (SPAST 产品)
- 别名
- CG5977 antibody, D-spastin antibody, Dmel\\CG5977 antibody, Dspastin antibody, Spas antibody, zgc:85952 antibody, SPAST antibody, spg4 antibody, LOC100224472 antibody, ADPSP antibody, FSP2 antibody, SPG4 antibody, Spg4 antibody, mKIAA1083 antibody, spastin antibody, spastin S homeolog antibody, spas antibody, spast antibody, SPAST antibody, Spast antibody, spast.S antibody
- 背景
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ADPSP, FSP2, Spast, Spatin, SPG4,Spastin
Cellular localisation: Cell Membrane and Secreted. - 分子量
- 52kDa
- 基因ID
- 6683, 468091
- 途径
- Microtubule Dynamics, M Phase, Regulation of Cell Size
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