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PTH 抗体 (AA 1-34, AA 32-115)

PTH 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal 3H9-PTH-1175 unconjugated
产品编号 ABIN6938258
发货至: 中国
  • 抗原 See all PTH 抗体
    PTH (Parathyroid Hormone (PTH))
    抗原表位
    • 31
    • 25
    • 18
    • 14
    • 10
    • 9
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-34, AA 32-115
    适用
    • 159
    • 9
    • 9
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    宿主
    • 100
    • 69
    • 15
    • 2
    小鼠
    克隆类型
    • 100
    • 84
    单克隆
    标记
    • 116
    • 20
    • 13
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PTH antibody is un-conjugated
    应用范围
    • 68
    • 63
    • 57
    • 47
    • 40
    • 26
    • 22
    • 16
    • 13
    • 9
    • 8
    • 7
    • 6
    • 5
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    特异性
    Epitope of this MAb maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
    交叉反应 (详细)
    Human. Predicted to react with Mouse. Rat. Rabbit. Cow. Dog. Pig. Deer. Orangutan.
    纯化方法
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    免疫原
    A synthetic peptide around aa 1-34 of human mature-PTH-polypeptide (exact sequence is proprietary) (3H9), A recombinant fragment around aa 32-115 of human mature PTH-polypeptide (exact sequence is proprietary)
    克隆位点
    3H9-PTH-1175
    亚型
    IgG2b kappa
    Top Product
    Discover our top product PTH Primary Antibody
  • 应用备注

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: Human parathyroid gland carcinoma.

    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    储存液
    Azide free
    储存条件
    -20 °C,-80 °C
    储存方法
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    有效期
    24 months
  • 抗原
    PTH (Parathyroid Hormone (PTH))
    别名
    PTH (PTH 产品)
    别名
    PTH1 antibody, Pthp antibody, PTH-(1-84) antibody, Pth1 antibody, Pthr1 antibody, PTH antibody, parathyroid hormone antibody, parathyroid hormone S homeolog antibody, PTH antibody, Pth antibody, pth.S antibody
    物质类
    Hormone
    背景
    HPTH, Parathormone, Parathyrin, Parathyroid hormone 1 (PTH1), Parathyroid hormone (PTH),Parathyroid Hormone (PTH) (N- & C-Terminal)
    Cellular localisation: Cytoplasmic and Secreted
    分子量
    9kDa
    基因ID
    5741, 37045
    UniProt
    P01270
    途径
    cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process
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