Peroxiredoxin 4 抗体
Quick Overview for Peroxiredoxin 4 抗体 (ABIN6938231)
抗原
See all Peroxiredoxin 4 (PRDX4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human PRDX4 protein
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亚型
- IgG2b kappa
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anti-Peroxiredoxin 4 (PRDX4) (AA 1-271) antibody
PRDX4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) antibodyPRDX4 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 178-2081), (C-Term) antibodyPRDX4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 6-249) antibodyPRDX4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 14-258) antibodyPRDX4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 51-150) antibodyPRDX4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2C12 unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 38-271) antibodyPRDX4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 82-110) antibodyPRDX4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB20891 unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 89-118), (Middle Region) antibodyPRDX4 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) antibodyPRDX4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
Positive_Control: HepG2, HeLa and Jurkat cell lysates. Ovarian carcinoma tissue.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- Peroxiredoxin 4 (PRDX4)
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别名
- PRDX4
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背景
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Antioxidant enzyme AOE372, EC 1.11.1.15, Thioredoxin dependent peroxide reductase A0372, TRANK,Peroxiredoxin 4 (Prognostic Marker for Lung SqCC)
Cellular localisation: Cytoplasm. Secreted. -
分子量
- 27kDa
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基因ID
- 10549, 83383
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UniProt
- Q13162
抗原
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