MTF1 抗体
Quick Overview for MTF1 抗体 (ABIN6937919)
抗原
See all MTF1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.
-
交叉反应 （详细）
- Human.
-
纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
-
免疫原
- Recombinant full-length human MTF1 protein
-
亚型
- IgG1 kappa
-
-
anti-Metal-Regulatory Transcription Factor 1 (MTF1) (AA 2-139) antibody
MTF1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Metal-Regulatory Transcription Factor 1 (MTF1) (AA 41-140) antibodyMTF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E5 unconjugated
anti-Metal-Regulatory Transcription Factor 1 (MTF1) antibodyMTF1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal MTF1-2649 unconjugated
anti-Metal-Regulatory Transcription Factor 1 (MTF1) (AA 101-200) antibodyMTF1 适用: 人 ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Metal-Regulatory Transcription Factor 1 (MTF1) (AA 562-611) antibodyMTF1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Metal-Regulatory Transcription Factor 1 (MTF1) (AA 2-164) antibodyMTF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Human kidney.
-
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
-
储存液
- Azide free
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
-
有效期
- 24 months
-
-
- MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))
-
别名
- MTF1
-
背景
-
Metal regulatory transcription factor 1, Metal response element binding transcription factor 1, Metal responsive transcription factor 1, MRE-binding transcription factor 1, MTF1, Transcription factor MTF1, Zinc regulatory factor (ZRF),MTF1
Cellular localisation: Nucleus. -
分子量
- 70kDa
-
基因ID
- 4520, 471991
-
UniProt
- Q14872
抗原
-
