Recombinant MTAP 抗体 (AA 97-196)
Quick Overview for Recombinant MTAP 抗体 (AA 97-196) (ABIN6937917)
抗原
See all MTAP 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 97-196
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特异性
- Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary)
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亚型
- IgG1 kappa
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anti-Methylthioadenosine phosphorylase (MTAP) (AA 1-154) antibody
MTAP 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G4 unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 1-283) antibodyMTAP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) antibodyMTAP 适用: 人 WB, IP, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 97-196) antibodyMTAP 适用: 人 WB, IHC, ELISA, Coat, StM 宿主: 兔 Monoclonal MTAP-3137R unconjugated Recombinant Antibody
anti-Methylthioadenosine phosphorylase (MTAP) (AA 97-196) antibodyMTAP 适用: 人 WB, IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal MTAP-1813 unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 97-196) antibodyMTAP 适用: 人 IHC, StM, ISt 宿主: 小鼠 Monoclonal rMTAP-1813 unconjugated Recombinant Antibody
anti-Methylthioadenosine phosphorylase (MTAP) (Internal Region) antibodyMTAP 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 1-283) antibodyMTAP 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 8-37), (N-Term) antibodyMTAP 适用: 人 WB 宿主: 兔 Polyclonal RB42759 unconjugated
anti-Methylthioadenosine phosphorylase (MTAP) (AA 1-283) antibodyMTAP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C8 unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: HepG2, A431, HeLa or MCF-7 cells. Human kidney tissues (IHC).
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- MTAP (Methylthioadenosine phosphorylase (MTAP))
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别名
- MTAP
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背景
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BDMF, DMSFH, DMSMFH, Epididymis luminal protein 249, HEL249, LGMBF, MeSAdo phosphorylase, Methylthioadenosine phosphorylase, MSAP, MTA phosphorylase, MTAPase, S-methyl-5''-thioadenosine phosphorylase,MTAP (Tumor Suppressor Marker)
Cellular localisation: Cytoplasmic -
分子量
- 31kDa
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基因ID
- 4507, 193268
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UniProt
- Q13126
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途径
- Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process
抗原
-
