Cytokeratin 1 抗体 (C-Term)
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Quick Overview for Cytokeratin 1 抗体 (C-Term) (ABIN6937639)
抗原
See all Cytokeratin 1 (KRT1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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原理
- Cytokeratin 1 (Suprabasal Keratinocyte Marker) Antibody
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特异性
- Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Cytokeratin 1 is a hetero-tetramer of two type I as well as two type II keratins, keratin-10 (KRT10). Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epithelia. Mutations in keratin 1 cause epidermolytic hyperkeratosis.
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交叉反应 (详细)
- Human. Rat.
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纯化方法
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- A 13-amino acid peptide (VRFVSTSYSGVTR) from the C-terminus of human KRT1 protein
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亚型
- IgG2a, kappa
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Skin or Cervix.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))
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别名
- KRT1
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背景
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67 kDa Cytokeratin, CK1, Cytokeratin-1, EHK1, Epidermolytic hyperkeratosis 1, EPPK, K1, Keratin Type II Cytoskeletal 1, Keratin-1, KRT1, KRT1A, NEPPK, Type II cytoskeletal 1, Type-II keratin Kb1
Skin or Cervix.
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分子量
- ~67kDa
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基因ID
- 38748, 80828
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UniProt
- P04264
抗原
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