Human Papilloma Virus 16, 18 E6 (HPV-16, HPV-18 E6) 抗体
The 小鼠 单克隆 anti-Human Papilloma Virus 16, 18 E6 antibody (Clone HPV16-1295-HPV18-1297) (ABIN6937432) specifically detects Human Papilloma Virus 16, 18 E6 in ELISA 和 Coat.
The antibody is reactive with Human Papillomavirus 16 (HPV-16) samples.
产品编号 ABIN6937432
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Human Papilloma Virus 16, 18 E6 (HPV-16, HPV-18 E6) 抗体 (ABIN6937432)
抗原
Human Papilloma Virus 16, 18 E6 (HPV-16, HPV-18 E6)
适用
Human Papillomavirus 16 (HPV-16)
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
ELISA, Coating (Coat)
克隆位点
HPV16-1295-HPV18-1297
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纯化方法
- Purified by Protein A/G
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免疫原
- HPV18 E6-β-galactosidase fusion protein
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亚型
- IgG1 kappa
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anti-Human Papilloma Virus 16, 18 E6 (HPV-16, HPV-18 E6) antibody
HPV-16, HPV-18 E6 适用: Human Papillomavirus 16 (HPV-16), Human Papillomavirus 18 (HPV-18) IF (cc), IF (p), ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Positive Control: Human cervical cancer cells. Cervical tissue.
Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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缓冲液
- 10 mM PBS without BSA and without Azide.
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储存液
- Azide free
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.
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有效期
- 24 months
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- Human Papilloma Virus 16, 18 E6 (HPV-16, HPV-18 E6)
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别名
- HPV-16 E6 + HPV-18 E6 (Human Papilloma Virus 16/18)
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物质类
- Viral Protein
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背景
- Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.
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分子量
- 16/17kDa
抗原
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