HLA DQ 抗体
-
- 抗原 See all HLA DQ (HLA-DQ) products
- HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This HLA DQ antibody is un-conjugated
-
应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF), ELISA, Coating (Coat)
- 特异性
- Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.
- 交叉反应 （详细）
- Human. Pig.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- T4-positive CTL clone HG-38
- 克隆位点
- SPM422
- 亚型
- IgG2a kappa
-
anti-MHC Class II HLA-DQ (HLA-DQ) antibody
HLA-DQ 适用: 人, Pig FACS, IF, IHC (fro) 宿主: 兔 Monoclonal HLA-DQA1-2866R unconjugated Recombinant Antibody
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人, Pig FACS, IF 宿主: 小鼠 Monoclonal SPV-L3 unconjugated
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人, Pig FACS, IF, ELISA, Coat 宿主: 小鼠 Monoclonal SPM422 unconjugated
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal B-K27 unconjugated
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal B-K27 unconjugated
-
- 应用备注
-
Known_Application: ELISA (For coating, order antibody without BSA), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: Raji cells. Tonsil or lymph node.
- 限制
- 仅限研究用
-
- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
-
- 抗原
- HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))
- 别名
- HLA-DQ (HLA-DQ 产品)
- 背景
-
CELIAC1, DC 4 alpha chain Gluten sensitive enteropathy (celiac disease) (GSE), HLA Class II DQ, HLA class II histocompatibility antigen DQ, HLA class II histocompatibility antigen DQ(1) alpha chain, HLA class II histocompatibility antigen DQ(3) alpha chain, HLA DQA1, HLA DQB, HLA DQB1, IDDM1, Leucocyte antigen DQA1, Major histocompatibility complex class II DQ alpha 1, Major histocompatibility complex class II DQ beta 1, MHC class II antigen HLA DQ beta 1, MHC class II HLA DQ alpha 1, MHC class II HLA DQ beta glycoprotein, MHC DQ beta, MHC HLA DQ alpha,HLA-DQ (MHC II)
Cellular localisation: Cell surface - 分子量
- 60kDa
- 基因ID
- 3117, 3118, 3119
- UniProt
- P01908, P01909, P01920
-
