GNRHR and LHCGR (AA 1-29), (N-Term) 抗体
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Quick Overview for GNRHR and LHCGR (AA 1-29), (N-Term) 抗体 (ABIN6937330)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-29, N-Term
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原理
- GnRH-Receptor / LH-RH Receptor Antibody
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特异性
- Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.
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交叉反应 （详细）
- Human. Predicted to react with Pig, Rabbit.
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纯化方法
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor.
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亚型
- IgG1, kappa
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anti-GNRHR and LHCGR (AA 1-29), (N-Term) antibody
适用: 人, 大鼠 FACS, IF, IHC, WB 宿主: 小鼠 Monoclonal F1G4 unconjugated
anti-GNRHR and LHCGR antibody适用: 人 ELISA 宿主: 兔 Monoclonal GNRHR-2982R unconjugated Recombinant Antibody
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应用备注
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Known_Application: Optimal dilution for a specific application should be determined.
Positive_Control: T47D cells. Pituitary gland, ovarian or breast cancers.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- GNRHR and LHCGR
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背景
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GnRH receptor, GnRH-R, GNRHR1, gonadotropin-releasing hormone (type 1) receptor 1, GRHR, HH7, leutinizing-releasing hormone receptor, LHRHR, LRHR, luliberin receptor, luteinizing hormone releasing hormone receptor, Type I GnRH receptor
ovarian or breast cancers., T47D cells. Pituitary gland
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分子量
- 54-60kDa
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基因ID
- 2798, 3973, 407587468490
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UniProt
- P30968
抗原
-
