Emerin 抗体 (AA 56-167)
Quick Overview for Emerin 抗体 (AA 56-167) (ABIN6937146)
抗原
See all Emerin (EMD) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 56-167
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特异性
- Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human Emerin protein fragment (around aa 56-167) (exact sequence is proprietary)
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亚型
- IgG2b kappa
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anti-Emerin (EMD) (AA 56-167) antibody
EMD 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal EMD-2168 unconjugated
anti-Emerin (EMD) (AA 56-167) antibodyEMD 适用: 人 WB, IHC, IF, StM 宿主: 小鼠 Monoclonal EMD-2167 unconjugated
anti-Emerin (EMD) (AA 1-222) antibodyEMD 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 8F5A8 unconjugated
anti-Emerin (EMD) (AA 1-222) antibodyEMD 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Emerin (EMD) (AA 1-110) antibodyEMD 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3B9 unconjugated
anti-Emerin (EMD) (AA 1-254) antibodyEMD 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Emerin (EMD) (AA 1-220) antibodyEMD 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Emerin (EMD) antibodyEMD 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Emerin (EMD) (AA 1-188) antibodyEMD 适用: 人, 兔 WB, IF, ICC 宿主: 小鼠 Monoclonal MANEM1(5D10) unconjugated
anti-Emerin (EMD) (AA 114-183) antibodyEMD 适用: 小鼠, 大鼠, Hamster WB, IF, ICC, EM 宿主: 绵羊 Polyclonal unconjugated
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应用备注
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Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: K-562, HeLa or Jurkat cells. Kidney or Skin.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- Emerin (EMD)
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别名
- EMD
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背景
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EMD, Emerin, Emery Dreifuss muscular dystrophy (EDMD), STA,Emerin (Papillary Thyroid Carcinoma and EDMD Marker)
Cellular localisation: Nuclear Membrane -
分子量
- 37kDa
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基因ID
- 2010, 522823
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UniProt
- P50402
抗原
-
