Desmoglein 3 抗体 (AA 379-491)
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- 抗原 See all Desmoglein 3 (DSG3) 抗体
- Desmoglein 3 (DSG3)
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抗原表位
- AA 379-491
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Desmoglein 3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Coating (Coat)
- 特异性
- Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80 % ) and specificity (100 %) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
- 交叉反应 (详细)
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)
- 克隆位点
- DSG3-2796
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product DSG3 Primary Antibody
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- 应用备注
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Known_Application: ELISA (For coating, order Ab without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: A431 cells. Skin or Lung Squamous Cell Carcinoma (SCC).
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- Desmoglein 3 (DSG3)
- 别名
- DSG3 (DSG3 产品)
- 别名
- DSG3 antibody, CDHF6 antibody, PVA antibody, bal antibody, balding antibody, desmoglein 3 antibody, DSG3 antibody, Dsg3 antibody
- 背景
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130 kDa pemphigus vulgaris antigen (PVA), Balding (Bal), Cadherin family member 6 (CDHF6), Desmoglein-3 (DSG3),Desmoglein-3 (Squamous Cell Marker)
Cellular localisation: Cell Surface - 分子量
- 130kDa
- 基因ID
- 1830, 1925
- UniProt
- P32926
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