CPS1 抗体
Quick Overview for CPS1 抗体 (ABIN6937018)
抗原
See all CPS1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC's occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
-
交叉反应 （详细）
- Human. Dog.
-
纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
-
免疫原
- Recombinant human CPS1 protein
-
亚型
- IgG1 kappa
-
-
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 1361-1500) antibody
CPS1 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 1400-1500) antibodyCPS1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 8H8 unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (Middle Region) antibodyCPS1 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, Cow, 兔, 马, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (N-Term) antibodyCPS1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) antibodyCPS1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 1400-1501) antibodyCPS1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 8H8 unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 951-1000) antibodyCPS1 适用: 人, 大鼠, 小鼠, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 151-200) antibodyCPS1 适用: 人, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (N-Term) antibodyCPS1 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, Cow, 兔, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) antibodyCPS1 适用: 人, 犬 IHC, IF, StM 宿主: 小鼠 Monoclonal SPM615 unconjugated
-
-
应用备注
-
Known_Application: Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 1 mM EDTA, pH 7.5-8.5, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. Liver or Hepatocellular Carcinoma (HCC).
-
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
-
储存液
- Azide free
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
-
有效期
- 24 months
-
-
- CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
-
别名
- CPS1
-
背景
-
Carbamoyl-phosphate synthetase 1 (CPS1), Carbamoylphosphate synthetase 1, CPSase 1, CPSASE1,CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker)
Cellular localisation: Finely granular cytoplasmic -
分子量
- ~165kDa
-
基因ID
- 1373, 149252
-
UniProt
- P31327
-
途径
- Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process
抗原
-
