Complement 3d (C3d) (Acute Humoral Rejection Marker) (AA 1250-1450) 抗体
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Quick Overview for Complement 3d (C3d) (Acute Humoral Rejection Marker) (AA 1250-1450) 抗体 (ABIN6937012)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1250-1450
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原理
- Complement 3d (C3d) (Acute Humoral Rejection Marker) Antibody
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特异性
- The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH - and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa 1250-1450) of human C3 protein (exact sequence is proprietary)
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亚型
- IgG2b, kappa
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anti-Complement 3d (C3d) (Acute Humoral Rejection Marker) (AA 1250-1450) antibody
适用: 人 IHC 宿主: 小鼠 Monoclonal C3D-2891 unconjugated
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应用备注
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Positive Control: Human kidney or rejected renal transplant tissue.
Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Complement 3d (C3d) (Acute Humoral Rejection Marker)
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背景
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CPAMD1; Acylation stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment
Human liver cancer or rejected renal transplant tissue.
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分子量
- 35kDa (predicted)
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基因ID
- 718, 529053
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UniProt
- P01024
抗原
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