CDw17 抗体
适用: 人
FACS, IF
宿主: 小鼠
Monoclonal
HuLy-m13
unconjugated
-
- 抗原
- CDw17
- 适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- 非结合性
-
应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF)
- 特异性
- CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor )-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.
- 交叉反应 （详细）
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- β-2 Microglobulin associated proteins from a detergent lysate of human PBL
- 克隆位点
- HuLy-m13
- 亚型
- IgM kappa
-
-
- 应用备注
-
Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: Human PBL. Tonsil.
- 限制
- 仅限研究用
-
- 浓度
- 1.0 mg/mL
- 缓冲液
- Purified Ab WITHOUT BSA at 1.0mg/ml
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
-
- 抗原
- CDw17
- 背景
-
Lactosylceramide; LacCer; β-D-galactosyl-(1-4)-β-D-glucosyl-(1-1')-ceramide;CDw17,CDw17 (Lactosylceramide or LacCer)
Cellular localisation: Cell Surface - 分子量
- Not known
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