CA8 抗体
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- 抗原 See all CA8 抗体
- CA8 (Carbonic Anhydrase VIII (CA8))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CA8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.
- 交叉反应 (详细)
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant full-length human CA8 protein
- 克隆位点
- CPTC-CA8-2
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product CA8 Primary Antibody
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- 应用备注
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Known_Application: Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human cerebellum. Selective expression in purkinje cells. HEK-293 or K-562 cell lines.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- CA8 (Carbonic Anhydrase VIII (CA8))
- 别名
- CA8 (CA8 产品)
- 别名
- AW546993 antibody, Ca8 antibody, Cals antibody, Cals1 antibody, Carp antibody, wdl antibody, zgc:110118 antibody, CA-VIII antibody, CALS antibody, CAMRQ3 antibody, CARP antibody, carbonic anhydrase 8 antibody, carbonic anhydrase VIII antibody, CAH8 antibody, Car8 antibody, ca8 antibody, CA8 antibody
- 背景
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CA-VIII, CALS, CARP, MGC120502, MGC99509,Carbonic Anhydrase VIII
Cellular localisation: Cytoplasm. Cell surface. - 分子量
- 32.97kDa
- 基因ID
- 767, 654388
- UniProt
- P35219
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