MUC16 抗体
Quick Overview for MUC16 抗体 (ABIN6936546)
抗原
See all MUC16 (CA125) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs). Membrane-associated and secretory Mucins are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. Epithelial Mucins are large, secreted and cell surface glycoproteins crucial for adhesion modulation, signaling and epithelial cell protection. The number of repeats is highly polymorphic and varies among different alleles. The Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), Mucins 6-8, Mucins 11-13 and Mucins 15-17. The Mucin 16 protein (also commonly referred to as CA125), encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal domain. Mucin 16, an ovarian cancer-associated antigen, is used as a marker to monitor the progress of epithelial ovarian cancer. It is a hydrophilic membrane-associated protein that may be involved in vitamin A functions.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Full length native MUC16 protein Purified from human ovarian carcinoma
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亚型
- IgG1 kappa
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anti-Mucin 16, Cell Surface Associated (CA125) (AA 1-200) antibody
CA125 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 4C8C8 unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) (AA 13977-14117) antibodyCA125 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) antibodyCA125 适用: 人 IHC, StM 宿主: 兔 Monoclonal OCA125-2349R unconjugated Recombinant Antibody
anti-Mucin 16, Cell Surface Associated (CA125) (AA 2-258) antibodyCA125 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) (AA 14067-14328) antibodyCA125 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) antibodyCA125 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) antibodyCA125 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal MUC16-1860 unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) (AA 10329-10628) antibodyCA125 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) (AA 10329-10628) antibodyCA125 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2C4 unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) (C-Term) antibodyCA125 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: MDA-MB-468 cells. Ovarian Cancer.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))
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别名
- CA125
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背景
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CA125, Cancer antigen 125, MUC16, Mucin16, Ovarian cancer-related tumor marker CA125, Ovarian carcinoma antigen CA125,MUC16 / CA125 (Ovarian Carcinoma Marker)
Cellular localisation: Cell Surface and Secreted -
分子量
- >2,000kDa
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基因ID
- 94025, 432676
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UniProt
- Q8WXI7
抗原
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