Recombinant BCL6 抗体 (AA 256-389)
Quick Overview for Recombinant BCL6 抗体 (AA 256-389) (ABIN6936496)
抗原
See all BCL6 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 256-389
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特异性
- Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human bcl-6 protein fragment (aa256-389) (exact sequence is proprietary)
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亚型
- IgG1 kappa
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anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 501-600) antibody
BCL6 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IHC (fro), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (Internal Region) antibodyBCL6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 256-389) antibodyBCL6 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal BCL6-1527 unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (Internal Region) antibodyBCL6 适用: 人, 小鼠 WB, IHC (p), IP, ChIP 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 147-276) antibodyBCL6 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 2G1B6 unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (Internal Region) antibodyBCL6 适用: 人, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 519-547) antibodyBCL6 适用: 人, 小鼠 WB, IHC, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 256-389) antibodyBCL6 适用: 人 WB 宿主: 小鼠 Monoclonal BCL6-1475 unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 256-389) antibodyBCL6 适用: 人 IHC, ELISA, StM, Coat 宿主: 小鼠 Monoclonal BCL6-1982 unconjugated
anti-B-Cell CLL/lymphoma 6 (BCL6) (pSer333) antibodyBCL6 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Positive_Control: Raji or Ramos cells. Tonsil or Hodgkin's lymphoma.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
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别名
- BCL6
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背景
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B-cell lymphoma 5 protein, B-Cell Lymphoma 6 Protein, BCL5, BCL6, BCL6A, cys his2 zinc finger transcription factor, Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3), Zinc finger and BTB domain-containing protein 27 (ZBTB27), Zinc Finger Protein 51 (ZNF51), zinc finger transcription factor BCL6S,Bcl-6 (Follicular Lymphoma Marker)
Cellular localisation: Nuclear -
分子量
- 95kDa
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基因ID
- 604, 478588
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UniProt
- P41182
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途径
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus
抗原
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