Recombinant beta-2 Microglobulin 抗体
Quick Overview for Recombinant beta-2 Microglobulin 抗体 (ABIN6936453)
抗原
See all beta-2 Microglobulin (B2M) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes a protein of 12 kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 Molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 Molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 Molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
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交叉反应 （详细）
- Human. Non-Human primates.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human full-length B2M protein
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亚型
- IgG2b kappa
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anti-beta-2-Microglobulin (B2M) (AA 1-119) antibody
B2M 适用: 人 WB, ELISA, IF, IHC (p), RNAi, PLA 宿主: 小鼠 Monoclonal 3F9-2C2 unconjugated
anti-beta-2-Microglobulin (B2M) (AA 21-100) antibodyB2M 适用: 人 WB, FACS, IHC, ELISA 宿主: 小鼠 Monoclonal 3G5H8 unconjugated
anti-beta-2-Microglobulin (B2M) (AA 22-119) antibodyB2M 适用: 小鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal A2 unconjugated
anti-beta-2-Microglobulin (B2M) (AA 22-119) antibodyB2M 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-beta-2-Microglobulin (B2M) antibodyB2M 适用: 人, Non-Human Primate FACS, IHC, IF, StM 宿主: 小鼠 Monoclonal rB2M-961 unconjugated Recombinant Antibody
anti-beta-2-Microglobulin (B2M) antibodyB2M 适用: 人, Non-Human Primate WB, FACS, IHC, IF, StM 宿主: 小鼠 Monoclonal B2M-961 unconjugated
anti-beta-2-Microglobulin (B2M) antibodyB2M 适用: 人, Non-Human Primate IHC, StM 宿主: 小鼠 Monoclonal B2M-1118 unconjugated
anti-beta-2-Microglobulin (B2M) antibodyB2M 适用: 人 WB, FACS, ELISA, IP, ICC, IHC (p), RIA 宿主: 小鼠 Monoclonal B2M-01 unconjugated
anti-beta-2-Microglobulin (B2M) antibody (Biotin)B2M 适用: 人 WB, FACS, ELISA, IP, ICC, IHC (p) 宿主: 小鼠 Monoclonal B2M-01 Biotin
anti-beta-2-Microglobulin (B2M) antibodyB2M 适用: 人, Non-Human Primate FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal B2M-961 unconjugated
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应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HL-60 or HeLa cells. Melanomas and Lymphoma. Carcinoma of Stomach, Cervix, Endometrial, Kidney or Colon. Human kidney tissue lysates.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
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别名
- B2M
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背景
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B2M, Beta 2 microglobin, Beta 2 microglobulin, Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, Hdcma22p,Beta-2 Microglobulin (Renal Failure & Tumor Marker)
Cellular localisation: Cell Surface and Extracellular (Secreted) -
分子量
- 12kDa
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基因ID
- 567, 534255
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UniProt
- P61769
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途径
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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