Uromodulin 抗体 (AA 351-450) (Biotin)
Quick Overview for Uromodulin 抗体 (AA 351-450) (Biotin) (ABIN678475)
抗原
See all Uromodulin (UMOD) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 351-450
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Cow
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from Human Uromodulin
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亚型
- IgG
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- Uromodulin (UMOD)
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别名
- Uromodulin
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背景
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Synonyms: ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, medullary cystic kidney disease 2 autosomal dominant, Tamm Horsfall glycoprotein, Tamm Horsfall urinary glycoprotein, Tamm-Horsfall urinary glycoprotein, THGP, THP, Umod, UROM_HUMAN, Uromodulin.
Background: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Uromodulin, secreted form: Secreted into urine after proteolytical cleavage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.
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基因ID
- 7369
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UniProt
- P07911
抗原
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