PKD1 抗体 (AA 131-230)
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北京 101111
Quick Overview for PKD1 抗体 (AA 131-230) (ABIN678083)
抗原
See all PKD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 131-230
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交叉反应
- 人, 小鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Polycystin 1
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亚型
- IgG
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anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (AA 651-876) antibody
PKD1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (AA 615-753) antibodyPKD1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (AA 349-612) antibodyPKD1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (pSer910) antibodyPKD1 适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (pSer205) antibodyPKD1 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (Thr266), (Thr312) antibodyPKD1 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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: "Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells." in: Human pathology, Vol. 65, pp. 231-238, (2017) (PubMed).
: "Novel Transgenic Mouse Model of Polycystic Kidney Disease." in: The American journal of pathology, Vol. 187, Issue 9, pp. 1916-1922, (2017) (PubMed).
: "Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 31, pp. 11153-68, (2015) (PubMed).
: "Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors." in: Carcinogenesis, Vol. 34, Issue 6, pp. 1315-22, (2013) (PubMed).
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: "Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells." in: Human pathology, Vol. 65, pp. 231-238, (2017) (PubMed).
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- PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
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别名
- Polycystin 1
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背景
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Synonyms: PBP, Pc-1, TRPP1, Polycystin-1, Autosomal dominant polycystic kidney disease 1 protein, PKD1
Background: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
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基因ID
- 5310
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UniProt
- P98161
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途径
- Myometrial Relaxation and Contraction, Maintenance of Protein Location
抗原
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