WNK3 抗体 (AA 451-550)
Quick Overview for WNK3 抗体 (AA 451-550) (ABIN675713)
抗原
See all WNK3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 451-550
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交叉反应
- 人, 大鼠
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预测反应
- Mouse,Cow,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human WNK3 protein
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亚型
- IgG
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anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 500-600) antibody
WNK3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) antibodyWNK3 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 1-100) antibodyWNK3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H5 unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (C-Term) antibodyWNK3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 1018-1181) antibodyWNK3 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 1-100) antibodyWNK3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 431-480) antibodyWNK3 适用: 人, 小鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) antibodyWNK3 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (N-Term) antibodyWNK3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 1586-1616), (C-Term) antibodyWNK3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3339 unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- WNK3 (WNK Lysine Deficient Protein Kinase 3 (WNK3))
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别名
- WNK3 protein
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背景
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Synonyms: PRKWNK3, Serine/threonine-protein kinase WNK3, Protein kinase lysine-deficient 3, Protein kinase with no lysine 3, WNK3, KIAA1566
Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.
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基因ID
- 65267
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UniProt
- Q9BYP7
抗原
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