GABBR2 抗体 (AA 501-650)
Quick Overview for GABBR2 抗体 (AA 501-650) (ABIN674544)
抗原
See all GABBR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 501-650
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human GABA B Receptor 2
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亚型
- IgG
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anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 319-483) antibody
GABBR2 适用: 人 IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 5G7F7 unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (pSer783) antibodyGABBR2 适用: 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 861-912) antibodyGABBR2 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S81-2 unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 861-912) antibody (HRP)GABBR2 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S81-2 HRP
anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 861-912) antibody (FITC)GABBR2 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S81-2 FITC
anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 861-912) antibody (Biotin)GABBR2 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S81-2 Biotin
anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 861-912) antibody (PE)GABBR2 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S81-2 PE
anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 861-912) antibody (PerCP)GABBR2 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S81-2 PerCP
anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 861-912) antibody (APC)GABBR2 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S81-2 APC
anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 861-912) antibody (Atto 488)GABBR2 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S81-2 Atto 488
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))
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别名
- GABA B Receptor 2
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背景
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Synonyms: HG20, GPR51, GPRC3B, GABABR2, HRIHFB2099, Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, Gb2, G-protein coupled receptor 51, GABBR2
Background: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
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基因ID
- 9568
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UniProt
- O75899
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途径
- cAMP Metabolic Process
抗原
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