我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

RASSF1 抗体 (AA 145-260)

Name: RASSF1 抗体 (AA 145-260)
SKU: ABIN673764
Availability: OutOfStock

Cited in 2+ publications. The 兔多克隆 anti-RASSF1 antibody (ABIN673764) specifically detects RASSF1 in ELISA, IF (cc), IF (p), IHC (p) 和 IHC (fro). The antibody is reactive with 人, 小鼠和大鼠 samples.

Formalin-fixed and paraffin-embedded human oral squamous cell labeled with Anti-RASSF1A Polyclonal Antibody, Unconjugated (ABIN673764) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, PE conjugated used at 1:200 dilution for 40 minutes at 37°C. (RASSF1 抗体 (AA 145-260))

Formalin-fixed and paraffin embedded rat brain labeled with Anti-RASSF1A Polyclonal Antibody, Unconjugated (ABIN673764) at 1:200 followed by conjugation to the secondary antibody and DAB staining. (RASSF1 抗体 (AA 145-260))

IHC

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-RASSF1A Polyclonal Antibody, Unconjugated (ABIN673764) at 1:200 followed by conjugation to the secondary antibody and DAB staining. (RASSF1 抗体 (AA 145-260))

IHC

4 images

(2 references)

产品编号 ABIN673764

发货至: 中国

Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for RASSF1 抗体 (AA 145-260) (ABIN673764)

抗原

See all RASSF1 抗体

RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This RASSF1 antibody is un-conjugated

应用范围

ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

抗原表位
14

7

5

3

3

2

2

2

2

1

1

1

1

1

1

1

1
AA 145-260

交叉反应

人, 小鼠, 大鼠

预测反应

Cow,Sheep,Horse

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human RASSF1

亚型

IgG
anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (AA 101-340) antibody
RASSF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (Internal Region) antibody
RASSF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (AA 1-340) antibody
RASSF1 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 3F3 unconjugated

anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (Center) antibody
RASSF1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (AA 1-340) antibody
RASSF1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3F3 unconjugated

anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (AA 1-340), (Isoform A), (N-Term) antibody
RASSF1 适用: 人 WB, IF, EIA 宿主: 小鼠 Monoclonal 3F3 unconjugated

anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (AA 23-145) antibody
RASSF1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (AA 1-270) antibody
RASSF1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (AA 201-250) antibody
RASSF1 适用: 人, 小鼠, 大鼠, Cow, 马, Pig, 犬, 绵羊, 斑马鱼, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated

anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (C-Term) antibody
RASSF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Klacz, Wierzbicki, Wronska, Rybarczyk, Stanislawowski, Slebioda, Olejniczak, Matuszewski, Kmiec: "Decreased expression of RASSF1A tumor suppressor gene is associated with worse prognosis in clear cell renal cell carcinoma." in: International journal of oncology, Vol. 48, Issue 1, pp. 55-66, (2015) (PubMed).

Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: "CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine." in: Biochemical and biophysical research communications, Vol. 402, Issue 3, pp. 507-14, (2010) (PubMed).
抗原

RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

别名

RASSF1

背景

Synonyms: 123F2, RDA32, NORE2A, RASSF1A, REH3P21, Ras association domain-containing protein 1, RASSF1
Background: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF1 stimulation. Isoform A interacts with CDC2, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

基因ID

11186

UniProt

Q9NS23