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PYROXD1 抗体 (AA 48-230)

This anti-PYROXD1 antibody is a 兔 多克隆 antibody detecting PYROXD1 in WB, ELISA 和 IHC. Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN6719650
发货至: 中国

Quick Overview for PYROXD1 抗体 (AA 48-230) (ABIN6719650)

抗原

PYROXD1 (Pyridine Nucleotide-Disulphide Oxidoreductase Domain 1 (PYROXD1))

适用

  • 7
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人, 大鼠, 小鼠

宿主

  • 6
  • 1

克隆类型

  • 7
多克隆

标记

  • 7
This PYROXD1 antibody is un-conjugated

应用范围

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  • 3
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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 抗原表位

    • 2
    • 1
    • 1
    • 1
    • 1
    AA 48-230

    原理

    Anti-PYROXD1 Antibody Picoband®

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-PYROXD1 Antibody Picoband® (ABIN6719650). Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human PYROXD1 recombinant protein (Position: K48-N230).

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    ELISA, 0.1-0.5 μg/mL
    1. O'Grady, G. L., Best, H. A., Sztal, T. E., Schartner, V., Sanjuan-Vazquez, M., Donkervoort, S., Neto, O. A., Sutton, R. B., Ilkovski, B., Romero, N. B., Stojkovic, T., Dastgir, J., and 30 others. Variants in the oxidoreductase PYROXD1 cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. Am. J. Hum. Genet. 99: 1086-1105, 2016. 2. Zhang, J.-L., Zhao, W.-G., Wu, K.-L., Wang, K., Zhang, X., Gu, C.-F., Li, Y., Zhu, Y., Wu, J.-G. Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin. Arch. Virol. 150: 721-741, 2005.

    说明

    Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原

    PYROXD1 (Pyridine Nucleotide-Disulphide Oxidoreductase Domain 1 (PYROXD1))

    别名

    PYROXD1

    背景

    Synonyms: Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1, PYROXD1

    Tissue Specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

    Background: Pyridine nucleotide-disulphide oxidoreductase domain 1 is a protein that in humans is encoded by the PYROXD1 gene. It is mapped to 12p12.1. This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other proteins. The encoded protein belongs to the class I pyridine nucleotide-disulphide oxidoreductase family but lacks the C-terminal dimerization domain found in other family members and instead has a C-terminal nitrile reductase domain. It localizes to the nucleus and to striated sarcomeric compartments. Naturally occurring mutations in this gene cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. A pseudogene of this gene has been defined on chromosome 11.

    分子量

    50-56 kDa

    基因ID

    79912
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