SNRPN 抗体 (N-Term)
Quick Overview for SNRPN 抗体 (N-Term) (ABIN6719629)
抗原
See all SNRPN 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 11-39, N-Term
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原理
- Anti-SNRPN Antibody Picoband® (monoclonal, 6F12)
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序列
- QHIDYRMRCI LQDGRIFIGT FKAFDKHMN
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-SNRPN Antibody Picoband® (monoclonal, 6F12) (ABIN6719629). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human SNRPN, identical to the related mouse and rat sequences.
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亚型
- IgG2b
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anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (AA 46-95) antibody
SNRPN 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (AA 1-240) antibodySNRPN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (AA 1-100) antibodySNRPN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (Internal Region) antibodySNRPN 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
1.Bielinska, B., Blaydes, S. M., Buiting, K., Yang, T., Krajewska-Walasek, M., Horsthemke, B., Brannan, C. I. De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch. Nature Genet. 25: 74-78, 2000. 2.Cattanach, B. M., Barr, J. A., Evans, E. P., Burtenshaw, M., Beechey, C. V., Leff, S. E., Brannan, C. I., Copeland, N. G., Jenkins, N. A., Jones, J. A candidate mouse model for Prader-Willi syndrome which shows an absence of Snrpn expression. Nature Genet. 2: 270-274, 1992. 3.Geuns, E., De Rycke, M., Van Steirteghem, A., Liebaers, I. Methylation imprints of the imprint control region of the SNRPN-gene in human gametes and preimplantation embryos. Hum. Molec. Genet. 12: 2873-2879, 2003. -
说明
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Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
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别名
- SNRPN
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背景
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Synonyms: Small nuclear ribonucleoprotein-associated protein N, snRNP-N, Sm protein D, Sm-D, Sm protein N, Sm-N, SmN, Tissue-specific-splicing protein, SNRPN, HCERN3, SMN
Tissue Specificity: Expressed in brain and lymphoblasts.
Background: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs (snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.
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分子量
- 26 kDa
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基因ID
- 6638
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UniProt
- P63162
抗原
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