SCRIB 抗体 (AA 172-409) (DyLight 550)
Quick Overview for SCRIB 抗体 (AA 172-409) (DyLight 550) (ABIN7354662)
抗原
See all SCRIB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 172-409
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原理
- Anti-Human SCRIBBLE DyLight® 550 conjugated Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Human SCRIBBLE DyLight® 550 conjugated Antibody (ABIN5693286)-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human SCRIBBLE recombinant protein (Position: F172-K409).
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亚型
- IgG
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anti-Scribbled Homolog (SCRIB) antibody
SCRIB 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Scribbled Homolog (SCRIB) (AA 382-410), (N-Term) antibodySCRIB 适用: 人 WB 宿主: 兔 Polyclonal RB39490 unconjugated
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应用备注
- Flow Cytometry (Fixed), 1-3 μg/1x106 cells1. L E Dow, J S Kauffman, J Caddy, A S Peterson, S M Jane, S M Russell & P O Humbert (April 2007). "The tumour-suppressor Scribble dictates cell polarity during ed epithelial migration: regulation of Rho GTPase recruitment to the leading edge". Oncogene. 26 (16): 2272-82. 2. Yi Qin, Christopher Capaldo, Barry M. Gumbiner & Ian G. Macara (December 2005). "The mammalian SCRIB polarity protein regulates epithelial cell adhesion and migration through E-cadherin". JCB. 171 (6): 1061-71.
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说明
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Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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- SCRIB (Scribbled Homolog (SCRIB))
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别名
- SCRIB
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背景
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Synonyms: Protein scribble homolog, Scribble, hScrib, Protein LAP4, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Tissue Specificity: Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
Background: SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. In Drosophila melanogaster, SCRIB is involved in synaptic function, neuroblast differentiation, and epithelial polarization. Mechanistically, the human homolog is a scaffold protein linked to cellular differentiation centered on the regulation of epithelial as well as neuronal morphogenesis. Deficiency in SCRIB impairs many aspects of cell polarity and cell movement. SCRIB is also likely involved in establishing apical-basal polarity as well as progression from the G1 phase to S phase in the cell cycle as a result of its relationship with cell proliferation and exocytosis.
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分子量
- 39 kDa
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基因ID
- 23513
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UniProt
- Q14160
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途径
- Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Tube Formation, Synaptic Vesicle Exocytosis, Asymmetric Protein Localization
抗原
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